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Peptide Synthesis

Biology

Peptide Synthesis

Peptides are linear polymers of amino acids linked by amide bonds. Amide bonds are formed by linking an amine (NH3) group of one amino acid to a caroboxyl (COOH) group on another amino acid.

There are two main approaches used for peptide synthesis: Liquid-Phase Peptide Synthesis (LPPS) and Solid-Phase Peptide Synthesis (SPPS). SPPS is the most commonly used method. LPPS is only used for synthesising peptides containing 2-4 amino acids. SPPS is a cyclic process of cleaving the protecting group, removing cleaving agent by washing, coupling of the protected amino acid to the next amino acid in the desired sequence, removal of excess material by washing.

DC Biosciences offers synthesis of custom peptides with a huge range of sequence lengths, purities, scales and modifications:

  • Sequences from 3 amino acids long
  • Purities ranging from crude to >99%
  • Variety of Post-Translational Modifications (PTMs)
  • 1-1000mg scale
  • MS and HPLC validation
  • FLUORESCENCE LABELLING
    • 5-TAMRA
    • Dansyl
    • DTPA
    • Biotinylation
    • and many more ...
  • TERMINAL MODIFICATION
    • Phosphorylation
    • Amidation
    • Acetylation
    • Formylation
    • and many more ...
  • PEPTIDE CONJUGATION
    • Keyhole Limpet Haemocyanin (KLH)
    • Bovine Serum Albumin (BSA)
    • Ovalbumin
    • Myoglobin
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